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KMID : 0387420080190020151
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Korean Society of Oriental Neuropsychiatry
2008 Volume.19 No. 2 p.151 ~ p.163
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Effects of Antidementia on LMK02 in APP-transgenic Fly
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Kim Sang-Tae
Kang Hyung-Won
Han Pyeung-Lim
Cho Hyoung-Kwon
Kim Tae-Heon
Lyu Yeoung-Su
Son Hyung-Jin
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Abstract
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Objective : Recent studies indicate that the deposition of beta-amyloid () is related in the pathogenesis of Alzheimer’s disease (AD), but the underlying mechanism is still not clear.
Method : To investigate the potential cellular functions of APP and LMK02, we use transgenic drosophila as a model was treated with either LMK02, and the effect in APP expression was determined by climbing assay. LMK02 have been shown to be neuroprotective in fly model systems. We asked whether dietary supplementation with LMK02 would influence behavior and AD-like pathology in a transgenic fly model.
Result : LMK02 water extract have attenuated fly death in vivo. LMK02-treated fly increased percentage of flight ability more longly and survival ratio more than controls. APP-GRIM drosophila treated with LMK02 had significantly less accumulation of APP deposition in the eye and brain as compared to control drosophila.
Conclusion : These results suggest that LMK02 prevent APP-induced neurotoxicity through attenuating flies death induced by APP, and may be useful as potential therapeutic agents for AD.
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KEYWORD
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drosophila, APP, Alzhemiers disease, LMK02
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